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Bristol, City of

Principal Clinical ScientistNHS

Bristol, BS10 5NB Permanent £53,755 to £60,504
Posted 18 September 2026 Closing date 2 October 2026
Ashley Down (1.3 miles, direct) Oldland (Avon Valley Railway) (6.4 miles, direct) Public Transport Interchange (9.0 miles, direct)

Job summary

Principal Clinical Scientist in Clinical Biochemistry

We are looking for a highly motivated Clinical Scientist to join the Clinical Biochemistry team at Southmead Hospital, Bristol NHS Foundation Trust. This post offers the opportunity to develop specialist expertise in the areas of toxicology and antenatal screening within the Specialist and Manual Techniques section of the Clinical Biochemistry department. The post holder will also participate in the department's general clinical validation rota and contribute to the clinical and scientific leadership of the biochemistry automated laboratory.

Applicants must beHCPC registered as a Clinical Scientist, have an MSc or PhD in an area relevant to the discipline and have completed part 1 FRCPath. A broad range of experience in Clinical Biochemistry is essential, along with good team working and leadership skills. Previous experience in Toxicology is desirable.

The Clinical Biochemistry department is part of Severn Pathology, located at Southmead Hospital in purpose-built Pathology buildings and incorporating Blood Sciences, Genetics, Infection Sciences and Cellular Pathology. Following the formation of Bristol NHS Foundation Trust we will be working closely with colleagues across the City centre and Weston to develop fully integrated pathology services within a single organisation.

Main duties of the job

To take a leading role in managing clinical and scientific aspects of the toxicology and antenatal screening services. The toxicology service includes clinical and coronial drug testing, immunosuppressants, trace metals, iohexol clearance and cholinesterase phenotyping.

To interpret and report postmortem toxicology results and liaise with pathologists, coroners officers and staff from other toxicology laboratories.

To provide clinical and scientific input in the automated biochemistry laboratory service and contribute to the general clinical biochemistry validation rota (duty biochemist). This post also includes participation in the out-of-hours on-call rota for clinical advice.

Job description

As a Principal Clinical Scientist in Clinical Biochemistry the postholder will

  • be responsible for the day-to-day management of scientific aspects of the toxicology and antenatal screeningservices (incorporating clinical and coronial toxicology, cholinesterase and antenatal screening for trisomies), ultimately responsible to theConsultant Clinical Scientist.
  • Contribute to the clinical and scientific leadership of the automated clinical biochemistry service
  • Participate in the general biochemistry clinical validation rota, providing interpretation and clinical advice in general biochemistry and endocrinology, and participate in the out-of-hours on-call rota for clinical advice.
  • Interpret and report toxicology results and, in conjunction with the Consultant Clinical Scientist, produce postmortem toxicology reports for pathologists and coroners.
  • Take a lead role in the laboratory provision of the antenatal screening service (fetal anomaly screening program, FASP)

Please refer to the job description for more details

About us

Bristol NHS Foundation Trust brings together more than 28,000 staff to deliver over 160 clinical services across thirteen hospital locations, operating from three main sites at Southmead, Bristol city centre and Weston.

With an annual turnover of £2.3 billion, we are now one of the largest NHS trusts in the United Kingdom. Our hospitals are spread across Bristol and Weston, join us and you can enjoy the very best of both worlds; city living within a stone's throw of the countryside or beside the seaside, both with easy access to all that theSouth Westhas to offer.

Bristol NHS Foundation Trust values all people as individuals. As an equal opportunities employer actively working towards a diverse workforce we aim to recruit and retain a workforce which represents the rich diversity of the local population at all levels and are committed to designing our services around the needs of individual patients and those around them. Anonymous information will be used from your application in order to ensure we're meeting our pledge.

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